02-07-21

Targeting multiciliated cells using specific treatments, such as nasal sprays, can be an ideal strategy to curb COVID-19 infection in the early stages

 

Researchers uncovered that nasal multiciliated epithelial cells are a target for SARS-CoV-2 infection and replication in the upper airway during the early stages of COVID-19.

Researchers uncovered that nasal multi-ciliated epithelial cells are a target for SARS-CoV-2 infection and replication in the upper airway during the early stages of COVID-19. The findings imply that targeting ciliated cells of the nasal epithelium during the early stage of COVID-19 can be an ideal strategy to prevent SARS-CoV-2 propagation.

Study findings were published in the July 1, 2021, edition of the Journal of Clinical Investigation, a peer-reviewed medical journal covering biomedical research, published by the American Society for Clinical Investigation. A group of researchers, led by Director KOH Gou Young, from the Center for Vascular Research within the Institute for Basic Science, South Korea, uncovered the processes involved in the earliest stages of COVID-19 infection. Evidence was provided that in patients with COVID-19, SARS-CoV-2 is massively detected and replicated within the multi-ciliated cells.

Analyses revealed that SARS-CoV-2 mostly grew in the nasal ciliated cells, rather than other cells in the oral cavity. These results suggest that targeting ciliated cells of the nasal epithelium during the early stage of COVID-19 could be an ideal strategy to prevent the spread of SARS-CoV-2. This adds to the growing body of evidence that supports the importance of intervening in the nose when trying to reduce the spread of an airborne viral infection such as COVID-19, in particular during the early stages of infection.

Reference: Ji Hoon Ahn, et al. Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19. Journal of Clinical Investigation, 2021; 131 (13) DOI: 10.1172/JCI148517

 

 

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